The Laboratory of Retroviral Biochemistry research group was established in 1992 by Dr. József Tőzsér. Previously, he studied the specificity of HIV proteases in the laboratory of Dr. Stephen Oroszlan in the United States of America, in the Molecular Virology and Carcinogenesis Laboratory of the NCI-Frederick Cancer Research and Development Center. After this, a strong collaboration was established between these research groups, and with those of Dr. Irene T. Weber (Georgia State University) and Dr. John M. Louis (NIH), in the field of investigation and characterization of wild-type and mutant retroviral proteases’ specificity.
One of the major research interests of the LRB is to study the biochemistry and enzymology of retroviral replication, with an emphasis on the function and features of the viral protease (PR). LRB has also been involved in the application of retroviral-derived vectors in gene therapy. You can read more about the research group in the online journal of the Hungarian Biochemical Society (MBKE), in the combined September-December 2018 issue (in Hungarian language): https://www.mbkegy.hu/BiokemShow/2018/12/mbkegy_title_merged_sept_dec
